São Paulo, popularly known as Sampa, is the largest city in Brazil, the largest city in the southern hemisphere and Americas, and the world's seventh largest city by population. The metropolis is anchor to the São Paulo metropolitan area, ranked as the second most populous metropolitan area in the Americas and among the five largest metropolitan areas on the planet. São Paulo is the capital of the state of São Paulo, which is the most populous Brazilian state, and exerts strong regional influence in commerce and finance as well as arts and entertainment. São Paulo maintains strong international influence and is considered an Alpha World City. The name of the city honors Saint Paul.

The metropolis has significant cultural, economic and political influence both nationally and internationally. It houses several important monuments, parks and museums such as the Latin American Memorial, the Museum of the Portuguese Language, São Paulo Museum of Art and the Ibirapuera Park. The Paulista Avenue is the most important financial center of São Paulo. The city holds many high profile events, like the São Paulo Art Biennial, the Brazil Grand Prix Formula 1 Sao Paulo, Sao Paulo Fashion Week, ATP Brasil Open, and the São Paulo Indy 300.

It is home to the São Paulo Stock Exchange, the Future Markets, and the Cereal Market Stock Exchanges (the second largest stock exchange in the World, in market value). São Paulo has been home to several of the tallest buildings in Brazil, including the building Mirante do Vale, Italia, Altino Arantes, North Tower of the UNSCOM (United Nations Centre Enterprise) and many others.

People from the city of São Paulo are known as paulistanos, while paulistas designates anyone from the whole of São Paulo state, including the paulistanos. The city's Latin motto, which it has shared with the battleship and the aircraft carrier named after it, is Non dvcor, dvco, which translates as "I am not led, I lead."

The city, which is also colloquially known as "Sampa" or "Cidade da Garoa" (city of drizzle), is also known for its unreliable weather, the size of its helicopter fleet, its architecture, gastronomy, severe traffic congestion, and multitude of skyscrapers.