Rodrigo Borgia - also known as Pope Alexander VI, was Pope from 11 August 1492 to his death on 18 August 1503. He is one of the most controversial of the Renaissance popes, and his Italianized Valencian surname, Borgia, became a byword for libertinism and nepotism, which are traditionally considered as characterizing his papacy. His reputation is mostly drawn from his enemies, the Italian prelates and barons whose power he subverted.

Rodrigo adopted his mother's family name of Borja in 1455 following the elevation to the papacy of maternal uncle Alonso de Borja (Italianized to Alfonso Borgia) as Calixtus III.

He had a lot of mistresses, one of lexander's many mistresses the one for whom passion lasted longest was a certain Vannozza (Giovanna) dei Cattani, born in 1442, and wife of three successive husbands. The connection began in 1470, and she bore him four children whom he openly acknowledged as his own: Giovanni, afterwards duke of Gandia (born 1474), Cesare (born 1476), Lucrezia (born 1480), and Goffredo or Giuffre (born 1481 or 1482).