The first episode aired on January 29, 2006, and with the final episode airing on January 21, 2007, and ran for 49 episodes.

Seven years prior to the series, a meteorite struck the Shibuya district in Tokyo. An alien lifeform, known as the Worms, emerged from the meteorite and became a threat to humanity. Souji Tendou has trained seven years while waiting for the Kabuto Zecter so that he may properly take up the name of Kamen Rider Kabuto. He befriends ZECT agent and Hiyori's coworker Arata Kagami, who is the first person to know his identity as Kabuto, and combats ZECT's other affiliated and rogue Kamen Riders, all the while dealing with the Worm menace.